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h .05, incidence of all illnesses was higher in the second quarter of 2012 compared with the third quarter of?2012. Of 74 illnesses in 38 subjects in group 1 and 121 illnesses in 59 subjects in group 2, 29 (39.1%) and 59 (48.7%) were virus associated, respectively. duration, and treatment for acute illness with prednisone and antibiotics. Coronavirus-associated illnesses (percent of illnesses, group 1 vs group 2) were characterized by myalgias (21% vs?68%, .01), chills (50% vs 52%), dyspnea (71% vs 24%, .01), headache (64% vs 72%), malaise (64% vs 84%), cough (86% vs 68%), sputum production (86% vs 60%), sore throat (64% vs 80%), and nasal congestion (93% vs 96%). Conclusions Respiratory illnesses were commonly associated with coronaviruses and enteroviruses/rhinoviruses affecting chronically ill, older patients more than healthy, young adults. test was used to compare continuous variables. Statistical analysis was done using SAS/STAT software, SAS version 9.2 (SAS Institute, Inc, Cary, NC). Results We enrolled 100 subjects in group 1 and 101 subjects in group 2 between November 2009 and August 2011 in St Louis, Missouri. There were greater Vegfa proportions of men and subjects who ever smoked cigarettes in group 1 EC 144 than group 2 (Table?1 EC 144 ), and there were no gender differences in group 2 (data not shown). Heart disease was reported by 77.6% and lung disease was reported by 65.3% of group 1 patients. Table?1 Demographics, Medical History, and Smoking History of the 2 2 Patient Groups .0001, greater proportion of male individuals in group 1 than group?2. ?The CLDSI score was determined only in group 1 patients. ?Individuals with underlying lung disease could have 1 pulmonary analysis based on reported history and medical record review. .0001, greater proportion of individuals who ever smoked smoking EC 144 cigarettes in group 1 than in group?2. Ailments were reported and assessed in all calendar quarters, and the largest numbers of ailments occurred between the fourth quarter of 2010 and the second quarter of 2012, when the numbers of individuals being followed were highest (Number?1A ). Incidence rates for those ailments were highest in the 1st quarter of 2010, fourth quarters of 2010 and 2011, and second quarter of 2012. Incidence rates overall were lowest in the second and third quarters of 2010 and third quarter of 2012 (Number?1B). Coronavirus-associated ailments were not recognized in the third quarter of 2010 and 2012 (Number?1B). The decrease in the number of ailments during the last 4 quarters of the study was most likely due to the fewer quantity of individuals being actively adopted. Open in a separate window Number?1 Acute respiratory illnesses evaluated by calendar quarter. (A) Shown are the numbers of enrolled study subjects who were becoming actively adopted in the study for acute respiratory ailments by calendar quarter and the numbers of ailments, in association with viral illness or not, with onset during each calendar quarter. (B) Shown are EC 144 the numbers of enrolled subjects who were becoming actively adopted in the study for acute respiratory ailments by calendar quarter when more than 20 subjects were actively enrolled. The incidence rates of acute respiratory illness, determined as ailments per patient per year, are demonstrated by calendar quarter and association with viral illness or not. Comparisons of categoric variables were by 2-sided Fisher precise test. The All Ailments line includes the 95% confidence interval of the incidence rate for each calendar quarter. a .05, incidence of illnesses not associated with a virus illness was highest in the fourth quarter of 2010 compared with the third quarter of 2010 and first quarter of.